I'm not sure if you can do this with the software, but it would be good for lefthanders. I'm not sure what model you have, but most models have some sort of Navigational button or scroll wheel on the side that serves as a scrolling device. You could try to change the orientation of the screen to put the navigational device near your left hand if that helps. I wonder why a lefthander like Bill Gates didn't want the option to put the scroll on the left side? Hope this can help.